Institute of Neuroscience, NYCU
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Meei-Ling Tsaur Distinguished Professor
Laboratory of Pain & Drug Development
Lab Members Meng-Han Chen eric122821@gmail.com
Jhao-Jun Jian am0934056578@yahoo.com.tw
Chia-Yi Huang chiayea1028@gmail.com
Collaborator
Cheng-Chang Lien, MD/PhD (Institute of Neuroscience, National Yang-Ming University)
Jen-Kun Cheng, MD/PhD (Mackay Memorial Hospital, Department of Anesthesiology)
Ruey-Horng Rau, MD (Mackay Memorial Hospital, Department of Anesthesiology)
Honor
Yen-Ling Kuo won the 1st place in 2016 Institute of Neuroscience Thesis Oral Competition
Yen-Ling Kuo won the best award in 2016 National Yang-Ming University Thesis Poster Competition
Yen-Ling Kuo won the 4th place in 2016 National 3-Minute Thesis Oral Competition of Life Science
Chao-Fu Cheng won the 2nd place in 2015 Mackay Hospital Joint Conference Poster Competition
Research Interest 1.Developing novel drugs for neuropathic pain
2.Elucidating the pathological mechanisms underlying neuropathic pain
3.Studying the roles of K+ channels and their modulatory proteins in the nervous system
Neuropathic pain is a type of moderate to severe chronic pain that results from nerve injury or disorder. Neuropathic pain affects 7-10% of the global population, but less than half of patients report satisfactory pain relief from current treatments. In addition, current available drugs have serious unwanted side effects, such sleepiness from calcium channel blockers and physical dependence from opioids. K+ channels, which act to reduce the activity of pain-sensing neurons, have been suggested to be novel drug targets for neuropathic pain. Using neuropathic pain animal models, my lab analyzes the expression and function of several K+ channels and their modulatory proteins in pain-related neurons located in the dorsal root ganglion (DRG), dorsal spinal cord and brain, from molecular/cellular to behavioral levels. Furthermore, we are developing novel drugs for neuropathic pain.
Selective expression of Kv4.3 in IB4(+) nociceptors Kv4 channels in spinal dorsal horn neurons
Mirror-image pain Intrathecal cannulation
Invited Lectures/Publications
Cheng CF, Wang WC, Huang CY, Du PH, Yang JH, Tsaur ML* (2016) Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons. Journal of Comparative Neurology 524:846-873.(correspondent*) Wang WJ, Cheng CF, Tsaur ML* (2015) Immunohistochemical localization of DPP10 in rat brain supports the existence of Kv4/KChIP/DPPL ternary complex in neurons. Journal of Comparative Neurology 523:608-628. (*:correspondent) pdf Cheng CF, Cheng JK, Chen CY, Lien CC, Chu DC, Wang SY, Tsaur ML* (2014) Mirror-image pain is mediated by NGF produced from TNF alpha-activated satellite glia after peripheral nerve injury. Pain 155:906-920. (*:correspondent) pdf Huang CY,Chu D, Hwang WC, Tsaur ML* (2012) Co-expression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in developing rat forebrain. The Journal of Comparative Neurology 520:3650-3672. (*:correspondent) pdf Chu LC +, Tsaur ML+, Lin CS, Hung YC, Wang TY, Chen CC, JK Cheng JK (2011) Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. British Journal of Anaesthesia 106:699-705.(first authors+) pdf Lin CF+, Tsaur ML+, Lin CS, Chen CC, Huang YJ, Cheng JK (2009) Intrathecal gabapentin does not act as an HCN channel activator in the rat formalin test. European Journal of Anaesthesiology 26:821-824. (first authors+) pdf Chien LY, Jen-Kun Cheng JK, Chu DC , Cheng CF, Tsaur ML* (2007) Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. Journal of Neuroscience 27:9855-9865. (correspondent*) pdf supplementary Lin CS+, Tsaur ML+, Lin CF, Chen CC, Yang JR, Cheng JK (2007) Chronic intrathecal infusion of minocycline prevents the development of spinal nerve ligation-induced pain in rats. Regional Anesthesia and Pain Medicine 32:209-216.(first authors+) pdf Lu CL, Hsieh JC, Tsaur ML, Huang YH, Wang PS, Wu LL, Liu PY, FY Chang FY, Lee SD (2007) Estrogen rapidly modulates mustard oil–induced visceral hypersensitivity in conscious female rat: a role of CREB phosphorylation in spinal dorsal horn neurons. American Journal of Physiology-Gastrointestinal and Liver Physiology 292:G438-G446. pdf Huang HY, Liao CW, Chen PS, Tsaur ML* (2006) Transient expression of A-type K+ channel alpha subunits Kv4.2 and Kv4.3 in rat spinal neurons during development. European Journal of Neuroscience 23:1142-1150. (correspondent*) pdf Huang HY, Cheng JK, Shih YS, Chen PS, Wang CL, Tsaur ML* (2005) Expression of A-type K+ channel alpha subunits Kv4.2 and Kv4.3 in rat spinal lamina II excitatory interneurons and co-localization with pain-modulating molecules. European Journal of Neuroscience 22:1149-1157. (correspondent*) pdf Hsu YH, Huang HY, Tsaur ML* (2003) Contrasting expression of Kv4.3, an A-type K+ channel, in migrating Purkinje cells and other post-migratory cerebellar neurons. European Journal of Neuroscience 12:601-612. (correspondent*) pdf Tsaur ML*, Wu YL, Huang FL, Shih YH (2001) Localization of an A-type K+ channel alpha subunit Kv4.2 in rat brain. Chinese Journal of Physiology 44:133-141. (correspondent*) pdf Ju YT, Chang ACY, She BR, Tsaur ML, Hwang HM, Chao CCK, Cohen SN, Lin-Chao S (1998) Gas7: a novel gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. Proceedings of the National Academy of Sciences of the United States of America 95:11423-11428. pdf Tsaur ML*, Wan YC, Lai FP, Cheng HF (1997) Expression of B-type endothelin receptor gene during neural development. FEBS Letters 417:208-212. (correspondent*) pdf Tsaur ML*, Chou CC, Shih YH, Wang HL (1997) Cloning, expression and CNS distribution of Kv4.3, an A-type K+ channel alpha subunit. FEBS Letters 400:215-220. (correspondent*) pdf Stoffel M, Tokuyama Y, Trabb JB, German MS, Tsaur ML, Jan LY, Polonsky KS, Bell GI (1995) Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Biochemical and Biophysical Research Communications 212:894-899. pdf Tsaur ML, Menzel S, Lai FP, Espinosa R, Concannon P, Spielman RS, Hanis CL, Cox N.J, Beau MM, German MS, Jan LY, Bell G.I, Stoffel M (1995) Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with non-insulin dependent diabetes mellitus. Diabetes 44:592- 596. pdf Sheng M, Tsaur ML, Jan YN, Jan LY(1994) Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain. Journal of Neuroscience 14:2408-2417. pdf Sheng M, Tsaur ML, Jan YN, Jan LY (1992) Subcellular segregation of two A-type K+ channel proteins in rat central neurons. Neuron 9:271-284. PubMed Tsaur ML, Sheng M, Lowenstein DH, Jan YN, Jan LY (1992) Differential expression of K+ channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. Neuron 8:1055-1067. PubMed Baldwin TJ, Tsaur ML, Lopez GA , Jan YN, Jan LY (1991) Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel. Neuron 7:471-483. pdf Tsaur ML, Clowes R (1989) Localization of the control region for expressionof exotoxin A in Pseudomonas aeruginosa. Journal of Bacteriology 171: 2599-2604. pdf Lee CY, Tsai MC, Tsaur ML, Lin WW, Carlsson, FHH, Joubert FJ (1985) Pharmacological study on Angusticeps-type toxin from mamba venoms. Journal of Pharmacology and Experimental Therapeutics 233:491-498. pdf Lee CY, Lee JL, Tsaur ML (1982) Effects of a crotamine-like toxin from Crotalus h. horridus venom on skeletal neuromuscular transmission. Journal of Formosan Medical Association 81:833-842.
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