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Institute of Neuroscience, NYMU
Ching-Po Lin Distinguished Professor

Laboratory of Brain Connectivity

Ching-Po Lin Distinguished Professor



Lab Homepage

Lab Members

吳青芳 黃明浩 劉一萱 張舜泰 林尚樺 黃俊肇


Research Interest

Our laboratory applies well-developed diffusion MRI technique to interdisciplinary researches, including psychology, physiology, medicine, and engineering application. 
In psychology, we combine several modalities such as TMS, MRI, MEG, and EEG to explore brain functions related to different reactions and behaviors. MRI can provide high resolution anatomical images and also show the microstructure through diffusion techniques. TMS helps to map brain regions conducting reactions such as swallowing, muscular twitch, and flash. And MEG or EEG, which shows signal transmission under specific stimulus, is used to obtain the temporal information. By integrating different modalities, brain functions can be fully revealed.
In physiology, we adopt diffusion MRI techniques to reveal tissue structure such as cerebral neuronal tracts, and some deep nucleus. Using FA and ADC indices, which are derived from diffusion MRI, we correlate these indices with psychometrics and also with their correspondence to some abnormalities. It is very helpful to identify abnormal brain regions in vivo.
In medicine, diffusion MRI is exploited to pre-diagnose and to predict the recovery before and after the operation of brain tumor. Through inter-group comparison between normal subjects and patients, we can easily reveal the changes of schizophrenia and ADHD patients, which can just be diagnosed by psychometrics and doctor’s experience. Furthermore, axonal regeneration with stem cell can also be detected by using tractography technique, which is derived from diffusion MRI. Also, we apply diffusion MRI to research of stroke using rat. Diffusion MRI can enhance the contrast of different level of stroke and is helpful to researches of trauma.
In engineering, we develop fiber tracking techniques of different diffusion MRI technique such as diffusion spectrum imaging, which can give detailed information of microstructure. Besides, fundaments of diffusion MRI related to tissue microstructure can be clarified progressively in present researches. More detailed understanding makes MRI or diffusion MRI feasible for more applications, such as myelin degeneration.
More research in our lab are also in progress, such as automatic segmentation of the brain, mapping fiber density by diffusion MRI, Monte-Carlo model of diffusion phenomenon, correlation between reaction-time and diffusion MRI, virtual reality, software development and so on.
Invited Lectures/Publications
Chun-Yi Lo, Pei-Ning Wang, Kun-Hsien Chou, Jinhui Wang, Yong He*, Ching-Po Lin*. 2010 “Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer’s disease” Journal of Neuroscience (In press).

Kun-Hsien Chou, Yawei Cheng, I-Yun Chen, Ching-Po Lin*, Woei-Chyn Chu *. 2010 “Sex-Linked White Matter Microstructure of the Social and the Analytic Brain” NeuroImage (In press).

Kuen-Jer Tsai, Chun-Hung Yang, Yen-Hsin Fang, Kuan-Hung Cho, Wei-Lin Chien, Wei-Ting Wang, Tzu-Wei Wu, Ching-Po Lin, Wen-Mei Fu, Che-Kun James Shen. 2010 “Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U” Journal of Experimental Medicine (In press).

Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2010 “Persistent ictal-like visual cortical excitability in chronic migraine” Pain (In press).

Yawei Cheng, Chen-Yi Chen, Ching-Po Lin, Kun-Hsien Chou, Jean Decety. 2010 “Love hurts: an fMRI study” NeuroImage 51(2): 923-929.

B. B. Biswal, M. Mennes, X. Zuo, S. Gohel, C. Kelly, S. M. Smith, C. F. Beckmann, J. S. Adelstein, R. L. Buckner, S. Colcombe, A. Dogonowski, M. Ernst, D. Fair, M. Hampson, M. J. Hoptman, J. S. Hyde, V. J. Kiviniemi, R. K尒ter, S. Li, C. P. Lin, M. J. Lowe, C. Mackay, D. J. Madden, K. H. Madsen, D. S. Margulies, H. S. Mayberg, K. McMahon, C. S. Monk, S. H. Mostofsky, B. J. Nagel, J. J. Pekar, S. J. Peltier, S. E. Petersen, V. Riedl, S. A. Rombouts, B. Rypma, B. L. Schlaggar, S. S. Seidler, G. J. Siegle, C. Sorg, G. Teng, J. Veijola, A. Villringer, M. Walter, L. Wang, X. Weng, S. Whitfield-Gabrieli, P. Williamson, C. Windischberger, Y. Zang, H. Zhang, F. X. Castellanos, M. P. Milham, 2010 “Towards discovery science of human brain function” Proceedings of the National Academy of Sciences 107:4734-4739.

Chun-Hung Yeh, J.-Donald Tournier, Kuan-Hung Cho, Ching-Po Lin*, Fernando Calamante, Alan Connelly. 2010 “The Effect of Finite Diffusion Gradient Pulse Duration on Fibre Orientation Estimation in Diffusion MRI” NeuroImage 51: 743-751.

Yawei Cheng, Kun-Hsien Chou, I-Yun Chen, Yang-Teng Fan, Jean Decety, Ching-Po Lin*. 2010 “Atypical Development of Frontal Fractional Anisotropy in Adolescents with Autism Spectrum Disorder” NeuroImage, Apr; 50(3): 873-882.

Erick Jorge Canales-Rodríguez+, Ching-Po Lin+, Yasser Iturria-Medina, Chun-Hung Yeh, Kuan-Hung Cho, Lester Melie-Garcia. 2010 “Diffusion Orientation Transform Revisited” NeuroImage, Jan 15; 49(2): 1326-39.

Cheng-Ta Li, Ching-Po Lin*, Kun-Hsien Chou, I-Yun Chen, Jen-Chuen Hsieh, Chia-Liang Wu, Wei-Chen Lin, Tung-Ping Su*. 2010 “Structural and cognitive deficits in remitted and non-remitted recurrent depression: A voxel based morphometric study” NeuroImage, 50: 347–356.

Ke-Hsin Chen, Hsin-Ya Fan, Su-Ping Tsao, Yi-Ping Chao, Ching-Po Lin*. 2010 “Probabilistic Language Pathways Based HARDI Tractography” Chinese Journal of Magnetic Resonance, 27(3):1-8.

Yu-Ming Chuang, Wanyuo Guo, Ching-Po Lin. 2010 “Appraising the Plasticity of the Circle of Willis: A Model of Hemodynamic Modulation in Cerebral Arteriovenous Malformations” European Neurology, 63: 295–301.
Yi-Ping Chao, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and HARDI-tractography” Human Brain Mapping, Oct; 30(10): 3172-87.
Kuan-Hung Cho, Chun-Hung Yeh, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Potential in reducing scan times of HARDI by accurate correction of the cross-term in a hemi-spherical encoding scheme” Journal of Magnetic Resonance Imaging, Jun; 29(6): 1386-94.
Wei-Che Lin, Cheng-Hsien Lu, Yu-Chang Lee, Hung-Chen Wang, Chun-Chung Lui, Yu-Fan Cheng, Yi-Ting Shih, Ching-Po Lin*. 2009 “White matter damage in carbon monoxide intoxication assessed in vivo using diffusion tensor MRI” American Journal of Neuroradiology, Jun; 30(6): 1248-55.
Meng-Rui Lee, Yu-Ming Chuang, Wen-Jone Chen, Ching-Po Lin. 2009 “Meticulous blood pressure control is mandatory for symptomatic primitive trigeminal artery” Am J Emerg Med, 27 (5) pp. 634.e5-7.
Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2009 “Peri-ictal Normalization of Visual Cortex Excitability in Migraine: an MEG Study” Cephalalgia, 29: 1202-1211.
Xiujuan Geng, Thomas J. Ross, Wang Zhan, Hong Gu, Yi-Ping Chao, Ching-Po Lin, Gary E. Christensen, Norbert Schuff, Yihong Yang. 2009 “Diffusion MRI registration using orientation distribution functions” Inf Process Med Imaging 21: 626-37.
Yu-Ming Chuang, Ching-Po Lin, Ho-Fai Wong, Yeu-Jhy Chang, Chien-Hung Chang, Ting-Yu Chang, Tai-Cheng Wu, Hsiu-Chuan Wu, Tsong-Hai Lee. 2009 “Plasticity of Circle of Willis: A longitudinal Observation of Flow Patterns in the circle of Willis One Week After Stenting for Severe Internal Carotid Artery Stenosis” Cerebrovascular Diseases, Apr 24; 27(6): 572-578.
Yu-Ming Chuang, Chien-Chih Chen, Ching-Po Lin. 2009 “Vertebral artery hypoplasia may contribute to abnormal vestibular evoked myogenic potential” Acta Neurol Taiwan, Jun; 18(2): 113-7.
Ya Mei Bai, Kun-Hsien Chou, Ching-Po Lin*, I-Yun Chen, Cheng-Ta Li, Yang Kai Chun, Tung-Ping Su*. 2009 “White Matter Abnormalities in Schizophrenia Patients with Tardive Dyskinsia: A Diffusion Tensor Image Study” Schizophrenia Research, Apr; 109(1-3): 167-181.
Yawei Cheng, Kun-Hsien Chou, Jean Decety, I-Yun Chen, Daisy Hung, Ovid Jyh-Lang Tzeng, Ching-Po Lin*. 2009 “Sex Differences in the Neuroanatomy of Human Mirror-Neuron System: a Voxel-Based Morphometric Investigation” Neuroscience, Jan; 158(2): 713–720.
Kuan-Hung Cho, Chun-Hung Yeh, Jacques-Donald Tournier, Yi Ping Chao, Jyh-Horng Chen*, Ching-Po Lin*. 2008 “Evaluation of the accuracy and angular resolution of Q-ball imaging” NeuroImage, Aug 1; 42(1): 262-271.
J-Donald Tournier, Chun-Hung Yeh, Fernando Calamante, Kuan-Hung Cho, Alan Connelly, Ching-Po Lin*. 2008 “Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion weighted imaging phantom data” NeuroImage, Aug 15; 42(2): 617-625.
Chun-Hung Yeh, Kuan-Hung Cho, Hsuan-Cheng Lin, Jiun-Jie Wang, Ching-Po Lin*. 2008 “Reduced Encoding Diffusion Spectrum Imaging Implemented with a Bi-Gaussian Model” IEEE Transactions on Medical Imaging, Oct; 27(10): 1415-24.
Yi-Ping Chao, Jyh-Horng Chen, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Ching-Po Lin*. 2008 “A Multiple Streamline Approach to High Angular Resolution Diffusion Tractography” Medical Engineering & Physics, Oct; 30(8): 989–996.
Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2008 “Posterior Communicating Artery Hypoplasia might Contribute to Acute Ischemic Stroke in the Absence of Carotid Artery Occlusion” Journal of Clinical Neuroscience, Dec; 15(12): 1376-1381.
Ching-Po Lin, Wan-Yuo Guo, Kun-Hsien Chou, Ming-Teh Chen, Min-Hsiung Chen, Yu-Shu Yen, Yi-Ping Chao, Donald Ming-Tak Ho. 2008 “Peri-tumoral Fractional Anisotropy Mapping as a Prognosticator and Treatment Guidance of Brain Tumors: A Feasibility Study” Journal of Medical and Biological Engineering, Sep; 28 (3): 139-145.
Yawei Cheng, Po-Lei Lee, Chia-Yen Yang, Ching-Po Lin, Jean Decety. 2008 “Gender Differences in the Mu Rhythm of the Human Mirror Neuron System” PLoS ONE, May 7; 3(5): e2113, 1-7.
Yawei Cheng, Chia-Yen Yang, Ching-Po Lin, Po-Lei Lee, Jean Decety. 2008 “The Perception of Pain in Others Suppresses Somatosensory Oscillations: A Magnetoencephalography Study” NeuroImage, May 1; 40(4): 1833-1840.
Erick J. Canales-RodríguezYasser Alemán-Gómez, Ching-Po Lin, Yasser Iturria-Medina, Pedro A. Valdés-HernándezLester Melie-García. 2008 “A Bayesian framework to identify principal intravoxel diffusion profiles based on Diffusion-Weighted MR Imaging” NeuroImage, Aug 15; 42(2): 750-770.
Erick Jorge Canales-RodríguezLester Melie-García, Yasser Iturria-Medina, Eduardo Martínez-MontesYasser Alemán-Gómez, Ching-Po Lin. 2008 “Inferring Multiple Maxima in Intravoxel White Matter Fiber Distribution” Magnetic Resonance in Medicine, Sep; 60(3): 616-630.
Jiun-Jie Wang, Yu-Chun Lin, Yau-Yau Wai, Hao-Li Liu, Ching-Po Lin, Ying-Zu Huang. 2008 “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach” Magnetic Resonance in Medicine, 59(4): 764-70.
Yu-Ming Chuang, Yuan-Chung Hwang, Ching-Po Lin*, Chih-Yang Liu. 2008 “Toward A Further Elucidation: Role of Vertebral Artery Hypoplasia in Migraine with Aura” European Neurology, 59(3-4): 148-151.
Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2007 “Anterior Cerebral Artery A1 Segment Hypoplasia May Contribute to A1 Hypoplasia Syndrome” European Neurology, Jan 19; 57(4): 208-211.
Yawei Cheng, Ching-Po Lin, Ho-Ling Liu, Yuan-Yu Hsu, Kun-Eng Lim, Daisy Hung, Jean Decety. 2007 “Expertise Modulates Pain Perception in Others” Current Biology, Oct 9; 17(19): 1708-1713.
Yawei Cheng, Jean Decety, Ching-Po Lin, Jen-Chuen Hsieh, Daisy Hung, Ovid J.L. Tzeng. 2007 “Sex differences in spinal excitability during observation of bipedal locomotion” Neuroreport, 18(9): 887-890.
Shih-Hwa Chiou, Chung-Lan Kao, Han-Tso Lin, Wen-Ser Tseng, Ren-Shyan Liu, Chen-Fun Chung, Hung-Hai Ku, Ching-Po Lin, Tai-Tong Wong. 2006 “Monitoring the Growth Effect of Xenotransplanted Human Medulloblastoma in Immunocompromised Mice Model Using In Vitro and Ex Vivo Green Fluorescent Protein Imaging” Childs Nervous System, 22: 485-490.
Ching-Po Lin, Van J. Wedeen, Ching Yao, Jyh-Horng Chen, Wen-Yih I. Tseng. 2003. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom” NeuroImage, Jul; 19(3): 482-495.
Ching-Po Lin, Wen-Yih Isaac Tseng, Hui-Cheng Cheng, Jyh-Horng Chen. 2001. “Validation of Diffusion Tensor Magnetic Resonance Axonal Fiber Imaging with Registered Manganese-enhanced Optic Tracts” NeuroImage, Nov; 14(5): 1035-1047.
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