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Yi-Hsuan Lee Professor
| Name |
Yi-Hsuan Lee
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| Position |
Professor |
| Tel. |
886-2-2826-7067 |
| Fax No. |
886-2-2826-4049 |
| E-mail |
yhlee3@ms.ym.edu.tw
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| Education |
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1993
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PhD
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Department of Physiology and Cell Biology, University of Kansas, Lawrence, Kansas, USA.
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1988
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BSc
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Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan.
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| Experience |
2017-2019, Distinguished Professor, National Yang-Ming University
2010-present Professor, National Yang-Ming University
2003-2010, Professor, Department of Physiology, Taipei Medical University
1995-2003, Associate Professor, Department of Physiology, Taipei Medical University
1994-1995, Associate Researcher, Department of Plastic Surgery, Chang Gung Memorial Hospital
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| Research Interests: |
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1. Molecular mechanisms of environmental stresses-associated neurodevelopmental and neuropsychiatric disorders. The environmental stresses include stress hormones (via glucocorticoid receptor), environmental pollutant (via aryl hydrocarbon receptor), and hypoxia (via hypoxia-inducible factors).
2. Roles of growth-associated protein 43 (GAP43) in the synaptic plasticity and astrocyte activity during neural development and post-injury repair.
3. Neuroprotective mechanisms underlying the prevention and therapy of white matter injuries.
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| Selected Recent Publications: |
| 1 |
Huang HJ, Wang YT, Lin HC, Lee YH*, Lin AM*. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. MOLECULAR NEUROBIOLOGY. 2018; 55(1):138-144. |
| 2 |
Huang SL, Chang CW, Lee YH, Yang FY*. Protective Effect of Low-Intensity Pulsed Ultrasound on Memory Impairment and Brain Damage in a Rat Model of Vascular Dementia. RADIOLOGY. 2017; 282(1):113-122. |
| 3 |
Hung CC, Lin CH, Chang H, Wang CY, Lin SH, Hsu PC, Sun YY, Lin TN, Shie FS, Kao LS, Chou CM, Lee YH*. Astrocytic GAP43 induced by the TLR4/NF-κB/STAT3 axis attenuates astrogliosis-mediated microglial activation and neurotoxicity. JOURNAL OF NEUROSCIENCE, 2016; 36(6):2027-43.
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| 4 |
Chou CC, Modi JP, Wang CY, Hsu PC, Lee YH*, Huang KF, Wang AH*, Nan C, Huang X, Prentice H, Wei J, Wu JY*. Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95). MOLECULAR NEUROBIOLOGY, 2017; 54(2):866-873.
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| 5 |
Wang CY, Lin HC, Song YP, Hsu YT, Lin SY, Hsu PC, Lin CH, Hung CC, Hsu MC, Kuo YM, Lee YJ, Hsu CY, Lee YH*. PKC-dependent GAP43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. MOLECULAR AND CELLULAR BIOLOGY 2015; 35(10): 1712–1726. |
| 6 |
Lee YH*, Lin CH, Hsu PC, Sun YY, Huang YJ, Zhuo JH, Wang CY, Gan YL, Hung CC, Kuan CY, Shie FS*. Aryl hydrocarbon receptor mediates both proinflammatory and antiinflammatory effects in lipopolysaccharide-activated microglia. GLIA 2015; 63(7):1138-1154. |
| 7 |
Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Lien CC, Kuan CY, Lee YH*. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.PLoS One 2013; 8(7):e69019. |
| 8 |
Lin MS, Hung KS, Chiu WT, Sun YY, Tsai SH, Lin JW,Lee YH*. Curcumin enhances neuronal survival in N-methyl-D-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATYR 2011;35(4):931-938. |
| 9 |
Lin MS, Sun YY, Chiu WT, Chang CY, Hung CC, Shie FS, Tsai SH, Lin JW, Hung KS, Lee YH*. Curcumin attenuates the expression and secretion of RANTES following spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro. JOURNAL OF NEUROTRAUMA 2011;28:1259-1269. |
| 10 |
Sun YY, Wang CY, Hsu MF, Juan SH, Chang CY, Chou CM, Yang LY, Hung KS, Xu J, Lee YH*, Hsu CY*. Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1α in a cell type-specific manner. JOURNAL OF NEUROSCIENCE 2010;30(28):9621-9630. |
| 11 |
Chang CY, Lee YH, Leu SJ, Wang CY, Wei CP, Hung KS, Pai MH, Tsai MD, Wu CH*. CCL18/PARC expression in the central nervous system with special reference to traumatic brain injuries and neoplastic disorders. NEUROSCIENCE 2010;165:1233-1243. |
| 12 |
Lin CH, Chen CC, Chou CM, Wang CY, Hung CC, Chen JY, Chang HW, Chen YC, Yeh GC, Lee YH*. Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. JOURNAL OF NEUROCHEMISTRY 2009;111:777-789. |
| 13 |
Lin CH, Juan SH, Wang CY, Sun YY, Chou CM, Chang SF, Hu SY, Lee WS, Lee YH*. Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons. JOURNAL OF NEUROCHEMISTRY 2008;104:1415-1429. |
| 14 |
Liu WL, Lee YH, Tsai SY, Hsu CY, Sun YY, Yang LY, Tsai SH, Yang WCV*. Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes. GLIA 2008;56:1390-1400 |
| 15 |
Tsai SY, Yang LY, Wu CH, Chang SF, Hsu CY, Wei CP, Leu SJ, Liaw J, Lee YH*, Tsai MD.. Injury Induced JAK/PKC-Dependent Phosphorylation of GAP-43 and STAT3 for Neurite Growth in Dorsal Root Ganglion. JOURNAL OF NEUROSCIENCE RESEARCH 2007;85:321-331. |
| 16 |
Chang SF, Sun YY, Yang LY, Tsai SY, Hu SY, Lee WS, Lee YH*. Bcl-2 gene family expression in the brain of rat offspring after gestational and lactational dioxin exposure. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 2005;1042:471-480. |
| 17 |
Lee HH, Yang LL, Wang CC, Hu SY, Chang SF, Lee YH*. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. BRAIN RESEARCH. 2003; 986(1-2):103-13. |
| 18 |
Lee YH*, Fang KM, Yang CM, Hwang HM, Chiu CT, Tsai W. Kainic acid-induced neurotrophic activities in developing cortical neurons. JOURNAL OF NEUROCHEMISTRY. 2000; 74(6):2401-11. |
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Research grant:
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1. Roles of growth-associated protein-43 in astrocyte reactivation in ischemic brain injury. (NSC)
2. Roles of the aryl hydrocarbon receptor in the NMDA receptor-mediated neuronal survival and death. (NHRI)
3. Molecular mechanisms of FKBP51-regulated oligodendrocyte survival and differentiation in ischemic brain injury
4. Aryl hydrocarbone receptor is a novel mediator of the kynurenine metabolism-induced neurodegeneration (NSC)
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| Lab membership: |
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Master Students: Ya-Yu Hu, Wan-Ci Chen,Su-Pei Hsu
PhD Students: Shang-Hsuan Lin, Yi-Min Kuo, Yu-Jie Huang, Yu-Ling Gan,Tzu-Yu Hsu
Postdoctoral fellow: Chia-Chi Hung
Research Assistant: Pei-Chien Hsu
Graduate (MS): Hsuan Chang, Yi-Jen Chang, Yu-Ling Gan, Chung-Han Weng, Po-Yi Lee,Yu-Ping Yeh, Hsiang-Yu Chuang, Sheng-Hui Wu,Chia-Yun Lee, Wen-Hua Chien, Rong-Heng Ho
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瀏覽數
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