Cheng-Ting Chien Professor

Laboratory of Drosophila Neural Development
image Cheng-Ting Chien   Professor( Adjunct )
Tel : 02-2788-3562
Fax : 02-2782-6085

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image The Drosophila peripheral nervous system is an excellent model to study neural development. One example is the specification of sensory neurons by proneural genes. My lab has also identified the proneural gene amos in controlling the formation of multi-dendritic (MD) neurons. The proneural proteins are bHLH transcriptional activators to promote neural precursor differentiation. We identified phyllopod (phyl) as a direct target gene of proneural proteins. The Phyl protein functions as a component of an ubiquitin ligase complex to degrade the neural repressor Tramtrack, thus promoting neural differentiation. Post-mitotic neurons grow extensively to form the axon and dendrites. We are studying the serine/threonin kinase Nak in dendrite formation. Nak functions to enhance endocytosis, thus promoting dendritic branching and growth.
image 2007/5/23-Pi, H.-W., Chien, C.-T.* (2007) Getting the edge: neural precursor selection. J. Biomedical Sci.
image Pi, H., Huang, S.-K., Tang, C.-Y., Sun, Y.-H. and Chien, C.-T., (2004) phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development. Proc. Natl. Acad. Sci. USA 101, 8378-8383
image Pi, H., Wu, H.-R., and Chien, C.-T., (2001) A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny. Development 128, 2699-2710.
image Huang, M.-L., Hsu, C.-H., and Chien, C.-T., (2000) The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Neuron 25, 57-67.
image Chen, C.-K. and Chien, C.-T., (1999) Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors. Proc. Natl. Acad. Sci. USA 96, 5055-5060.