Shih-Chieh Lin Professor

Shih-Chieh Lin, MD, PhD

Lab website

2017     Senior Investigator, National Institute on Aging, NIH, USA
2009-2017 Investigator, National Institute on Aging, NIH, USA
2006-2009 Postdoctoral Fellow, Duke University, USA
2001-2006 Ph.D., Neurobiology, Duke University, USA
1992-2000 M.D., National Taiwan University
2016 Post Baccalaureate Distinguished Mentor Award
2014 NIH Graduate Partnerships Program Outstanding Mentor Award
2014 European Neurasmus Scholar
2010 NARSAD 2010 Young Investigator Award
2009 Pathway to Independence (K99/R00) Award, NIMH, NIH
2008 NARSAD 2008 Young Investigator Award
Research Interest
Our research aims to understand how cognitive functions are mediated by interactions between cortical and subcortical circuits. The primary focus is to elucidate how the brain pays attention to motivationally salient stimuli and amplifies the associated cortical processing by engaging a key neural circuit we identified in recent years - salience-encoding neurons in the basal forebrain (BF). The laboratory combines multiple experimental approaches, including neuronal ensemble recording in behaving rats and mice, behavioral, optogenetic, pharmacological and computational techniques. Our ultimate goal is to develop therapeutic interventions that can be used to alleviate impairments in attention control in conditions such as aging, dementia, schizophrenia and attention deficit disorder.
Key Publications
1 Whitmore NW, Lin S-C (2016) Unmasking local activity within local field potentials (LFPs) by removing distal electrical signals using Independent Component Analysis. NeuroImage 132:79-92
2 Lin S-C, Brown RE, Hussain Shuler MG, Petersen CCH, Kepecs A (2015) Optogenetic dissection of the basal forebrain neuromodulatory control of cortical activation, plasticity and cognition. The Journal of Neuroscience 35(41):13896-903
3 Raver SM, Lin S-C (2015) Basal forebrain motivational salience signal enhances cortical processing and decision speed. Frontiers in Behavioral Neuroscience 9:277
Mayse JD, Nelson GM, Avila I, Gallagher M, Lin S-C (2015) Basal forebrain neuronal inhibition enables rapid behavioral stopping. Nature Neuroscience 18(10):1501-8
5 Avila I, Lin S-C (2014) Distinct neuronal populations in the basal forebrain encode motivational salience and movement. Frontiers in Behavioral Neuroscience 8:421
6 Mayse JD, Nelson GM, Park P, Gallagher M, Lin S-C (2014) Proactive and reactive inhibitory control in rats. Frontiers in Neuroscience, Decision Neuroscience section 8:104
7 Nguyen DP, Lin S-C (2014) A frontal cortex event-related potential driven by the basal forebrain. eLife 3:e02148
8 Avila I, Lin S-C (2014) Motivational salience signal in the basal forebrain is coupled with faster and more precise decision speed. PLOS Biology 12(3): e1001811
9 Lin S-C, Nicolelis MAL (2008) Neuronal ensemble bursting in the basal forebrain encodes salience irrespective of valence. Neuron 59(1):138-149
10 Lin S-C, Gervasoni D, Nicolelis MAL (2006) Fast modulation of prefrontal cortex activity by basal forebrain non-cholinergic neuronal ensembles. Journal of Neurophysiology 96(6):3209-19